Liver dysfunction in children with community-acquired pneumonia: the role of infectious and inflammatory markers

Markers of infectious-inflammatory process were studied by determining the levels pro-inflammatory cytokines - interleukin (IL) 1 and IL-6 proteins acute phase inflammation C-reactive protein (CRP) fibrinogen in serum children with community-acquired pneumonia. 
 It was found that course pneumonia is accompanied an increase concentrations IL-1 parallel disease severity. The synthesis stimulates production CRP, but reduces concentration sick children. revealed connections between content at systemic level multidirectional changes indicators indicate a violation liver, where are synthesized study.
 shown increasing severity pneumonia, enzyme activity aminotransferases alanine aminotransferase (ALT) aspartate (AST) increases simultaneous decrease de Ritis coefficient, indicating "hepatic" genesis. High closely correlated process, as indicated positive correlation ALT (r = 0.047) AST 0.111). At same time, there negative IL-1, CRP blood serum.